GPNA hydrochloride

CAS No. 67953-08-6

GPNA hydrochloride( —— )

Catalog No. M22681 CAS No. 67953-08-6

GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 39 In Stock
25MG 70 In Stock
50MG 120 In Stock
100MG 165 In Stock
500MG 413 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    GPNA hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT).
  • Description
    GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.GPNA (10-1000 μM; 48?hours) induces a dose-dependent to reduce of cell viability in A549 cells.
  • In Vitro
    GPNA (10-1000 μM; 48hours) induces a dose-dependent decrease of cell viability in A549 cells. Cell Viability AssayCell Line:A549 cells Concentration:10, 100, 250, 500 , and 1000 μM Incubation Time:48?hours Result:Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250?μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ASCT2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    67953-08-6
  • Formula Weight
    303.7
  • Molecular Formula
    C11H14ClN3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:124 mg/mL(408.3 mM)
  • SMILES
    Cl.N[C@@H](CCC(=O)Nc1ccc(cc1)[N+]([O-])=O)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.
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